10,000+ Happy Customers

Burning Gone. Tingling Vanished. Feeling Restored.

The topical built for the same nerves your pills are targeting, without asking your brain & sleep for payment.

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No Pill Side Effects

7-Active Nerve Formula

No Brain Fog

3-Phase Nerve Support

Get Your Life Back In Minutes

Then Keep It For Good.

If Gabapentin or Lyrica helped — but the side effects became their own problem

Brain fog. Dizziness. Weight gain. Swollen feet. For millions of people, the pills do quiet the nerve — but the cost is a body that feels half-asleep all day. Sepili targets the same misfiring nerves directly through the skin, so the actives concentrate where you need them instead of traveling through your whole bloodstream to get there.

 

Relief Without The Trade-Off

If you've tried magnesium or CBD creams and barely noticed

They're not bad products — they're aimed at the wrong target. Magnesium relaxes muscle. CBD calms surface tension. Your burning, pins-and-needles and electric shocks come from misfiring nerve fibres just below the skin — a different mechanism that needs a different cream. Sepili was built for that exact layer.

 

Built For The Right Target

It quiets the misfiring — burning, electric shocks, tingling at 2 AM

If your feet feel like they're sunburnt, like you're walking on broken glass, like pieces of leather are stuck to your soles — that's your nerves misfiring. Devil's Claw aids & repairs, and Menthol's TRPM8 pathway sends the signal to stop.

 

Sleep In Peace, Finally 

You feel it working in under 60 seconds — and it keeps working after

The cooling you feel the moment it touches your skin? That's not a trick. That's your nerves being told help is on the way. While most creams stop there, this one is just getting started — Devil's Claw keeps working underneath long after that first wave of relief hits.

 

Immediate Cooling, Lasting Comfort

Loved by people who tried gabapentin, Lyrica, lidocaine patches, B vitamins, magnesium — and finally found a topical built around the actual biology of nerve misfiring.

  • 3500+ 5-Star Reviews

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One Cream. Six Reasons It Works.

Most creams target the surface. Sepili was built for the kind of nerve pain that gabapentin and Lyrica only half-solve — and that magnesium, CBD, lidocaine and B12 never quite reached.

Burning Feet at 2 AM

That fire under your feet at night — sometimes described as "permanent sunburn" or "walking on glass" — is your nervous system misfiring. Menthol's TRPM8 activation sends a competing calm signal that overrides the broken alarm. Boswellia and Devil's Claw quiet the inflammation keeping the nerve hypersensitive. PEA targets the inflammatory glial cells driving the misfiring. Four mechanisms. One application.

Numbness, Tingling & Pins and Needles

Numbness comes from nerve fibres that have shut down. Tingling and pins and needles come from the surviving ones firing erratically. Benfotiamine and methylcobalamin — the active forms of B1 and B12 — are the exact molecular tools the nervous system uses to rebuild myelin and stabilise damaged fibres. Arnica improves local microcirculation so those rebuilding materials actually reach the nerves that need them.

Electric Shocks & Shooting Pain

The "electric current running down my legs" — the sudden shocks that make you jump — come from sodium channels stuck wide open and potassium channels switched off. Menthol's TRPM8 pathway recalibrates this directly, sending the nerve the signal to stop broadcasting. Phase II clinical trial data backs the mechanism specifically for neuropathic pain.

Dropping Things — Grip Failure

When peripheral nerves are damaged, the dying-back degeneration starts at the fingertips and works inward. Mugs slip. Pens are hard to hold. Buttoning a shirt becomes a battle. The rebuilding cofactors in Sepili (active B1, B12, NAD⁺ support via PEA) deliver locally to surviving fibres — giving them what they need to stabilise and improve fine-motor function over weeks of consistent use.

Sciatic & Shooting Leg Pain

When the sciatic nerve and the surrounding tissue are inflamed, every step becomes a calculation. Devil's Claw and Boswellia hit two distinct inflammatory pathways (COX-2 and 5-LOX) that NSAIDs don't address — without the gut, kidney, or liver risks. Apply along the affected nerve path; the actives concentrate at the tissue instead of being diluted across your entire bloodstream.

Sleep Disruption

If your feet hang off the bed because they burn too hot — or if your legs want to "kick and run" until 3 AM — Sepili's quieting layer engages within minutes of application. The deeper anti-inflammatory and nutritional repair layers work overnight while you finally rest.

  11,586+ 5-Star Reviews  

You Deserve Natural Relief.
Not Pharmaceutical Side-Effects.

Revolutionary Ingredients, Lasting Results.

  • Devil's Claw

  • Boswellia Serrata

  • Arnica

  • Menthol

  • PEA

  • Benfotiamine

  • Methylcobalamin

Devil's Claw

(Harpagophytum Procumbens) - 5% Harpagoside


Used across Europe & Southern Africa for centuries to quiet nerve inflammation — long before science had a name for why it worked. Now standardized to 5% harpagoside and HPLC-verified, it's the active ingredient no other pain cream on the market is built around. Your burning, your numbness, your flare-ups — this is what we built the formula for.


Sourced From Southern Africa

Boswellia Serrata

(Frankincense) - 65% Boswellic Acids & 8% AKBA


The active compound in frankincense, clinically studied to attack the neuro-inflammatory environment by inhibiting the 5-LOX enzyme — blocking the leukotriene production that lowers the firing threshold of damaged nerves. Reduces the inflammatory soup that keeps surviving fibres in a permanent state of hypersensitivity. Different mechanism from NSAIDs, without their gut and kidney side effects.


Sourced From India

Arnica

(Arnica Montana) - 5:1 Extract, 0.04% Sesquiterpene Lactones


Improves local microcirculation to the ischemic nerve territory — ensuring the rebuilding compounds in Layer 2 actually arrive at the damaged fibres. Simultaneously reduces local inflammatory signalling that keeps surviving nerves in a state of hypersensitivity.


Sourced From Europe

Menthol

(Mentha Arvensis) - 1.5%. USP grade, 99% purity


Not a scent. A pharmacological signal. Menthol binds to the TRPM8 receptor on peripheral sensory nerve fibres, sending a competing calm signal that overrides the spontaneous misfiring behind the burning and electric shocks. Published Phase II clinical trial data demonstrated 75% of neuropathy patients reported measurable pain reduction — and unlike numbing agents, the relief comes from quieting the nerve itself, not blocking sensation.


Naturally Derived

PEA (Palmitoylethanolamide)

95% standardised — Stop the fire


Once nerves start misfiring, the surrounding glial cells go into inflammatory overdrive — and that inflammation keeps the nerve in a permanent state of low-grade alarm. PEA quiets the inflammatory glial response, reducing the cytokine output (IL-1β, TNF-α) that perpetuates the burning. The only ingredient in the formula targeting the neuro-glial feedback loop at its source.


Naturally Derived

Benfotiamine

98% standardised - Rebuild the fibres


Standard thiamine bounces off nerve cell membranes. Benfotiamine — the fat-soluble form of B1 — actually crosses them and delivers the metabolic cofactor nerve fibres use for energy production and structural repair. Surviving fibres get the fuel they need to stabilise instead of fragment.


Naturally Derived

Methylcobalamin

99% standardised — Rebuild the fibres


The neurologically active form of B12 — not the cheap cyanocobalamin in generic supplements. Methylcobalamin directly participates in rebuilding the myelin sheath (the protective coating around your nerve fibres) and restoring axonal membrane integrity. The exact molecular tool the nervous system uses to repair itself — delivered topically so it actually arrives at the nerve.


Naturally Derived

Our Promise

90-Day Money Back Guarantee

You've already paid the bill for gabapentin or Lyrica, and the side effects on top. You've already tried the magnesium creams, the lidocaine patches, the B12 supplements that sat on the shelf for a week before getting tossed.

 

If 90 days from now you don't feel a meaningful difference in your burning, tingling, or numbness — every dollar comes back. No restocking. No hoops.

Feel the burning quiet down within minutes of the first application — or you don't pay

Designed to work alongside gabapentin, B12, and any existing protocol — no interactions

Built around the same TRPM8 mechanism backed by published Phase II clinical data

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The Cream That Sits Between You & Relief

Hear It From Those Who Switched

The Cream That Sits Between You & Relief

Hear It From Those Who Switched

Built For the Problem — Not Just One Symptom

Quiets the misfiring (burning, shocks)

Targets nerves, tendons, and tissue

Three botanicals working together

Topical Delivery — Straight To The Nerve

Skips first-pass liver metabolism

Concentrates at the affected tissue

No cognitive fog, no systemic side effects

Fast + Deep — Two-Phase Relief

Works on the misfiring within minutes

Botanicals build relief over weeks

Safe for everyday long-term use

Works With What You're Already Doing

No interactions with gabapentin or B12

Stacks with PT, stretching, magnesium

No NSAID risks to your gut or kidneys

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Trusted by Experts

Pain specialists and integrative medicine practitioners recognise Sepili's 3-layer mechanism as the first OTC topical built around the actual biology of nerve misfiring — instead of just numbing the skin above it.


Phase II Clinical Evidence · TRPM8-Pathway Mechanism

Powerful Ingredients. Proven Results.

89%

of patients experienced meaningful pain reduction — without a single NSAID*

82%

of neuropathic pain patients reported improvement in total pain scores after 4–6 weeks of topical treatment*

80%

reported satisfaction with botanical anti-inflammatory treatment after consistent use*

7

Standardised clinical-grade actives, delivered transdermally

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FAQs

If gabapentin or Lyrica are helping me, why would I add a cream?

Gabapentin and Lyrica genuinely do work for many people — they reach the nerves and they quiet the misfiring. The problem isn't whether they work. The problem is the cost: brain fog, dizziness, weight gain, double vision, and sometimes swelling of the very feet you're trying to help. That's because the drug travels gut → liver → bloodstream → entire body before it gets to the nerves in your feet. Sepili works at the same target with the opposite route — through the skin, concentrated locally — so you can lower the side-effect load without losing the relief. Many users layer the two; some eventually taper down with their doctor's supervision.

I've tried lidocaine patches. What makes this different?

Lidocaine numbs the skin's surface — it blocks the signal but doesn't fix what's broken. Once it wears off, the burning is back. Herbavera's TRPM8 pathway quiets the nerve itself (you keep normal sensation), while the B vitamins and PEA work on the inflammation and repair underneath. Relief that builds instead of resets to zero every 12 hours.

I've already tried magnesium or CBD cream. How is this different?

Magnesium relaxes muscles. CBD calms surface tension and stress response. Both are fine products — they're just aimed at a different layer than your problem. Burning, pins-and-needles and electric shocks come from nerve fibres misfiring just beneath the skin. Sepili uses menthol's TRPM8 pathway (clinically studied in neuropathic pain) to send a competing calm signal directly into that misfiring nerve, plus six other actives that target the inflammation around it and rebuild myelin. Different mechanism. Different target.

I take B12 already. Why would I need this too?

Oral B12 has to survive your stomach, get absorbed in your intestine, pass through your liver, and dilute across your whole body before any of it reaches the nerves in your hands and feet. Sepili's methylcobalamin (the active form of B12) is delivered topically — concentrated at the exact tissue where you need it. Use both together; they don't compete.

Will this work for my type of neuropathy?

The mechanisms Sepili targets — nerve misfiring, neuro-inflammation, and impaired myelin repair — are common across most peripheral neuropathies: diabetic, idiopathic, sciatic, post-injury, chemo-induced, and small fibre neuropathy. The closer the affected nerve is to the skin (feet, hands, calves, lower back), the more directly it gets reached.

How fast will I feel something?

The TRPM8 quieting effect is felt within minutes — that's the burning calming down. The deeper mechanisms (anti-inflammatory and nutritional repair) build over days and weeks of consistent use. Most users report meaningful change within 2–4 weeks of nightly application.

Can I use it with my current medications?

Yes. Because Sepili works locally and isn't systemically absorbed in meaningful amounts, it doesn't interact with gabapentin, Lyrica, duloxetine, oral B12, or magnesium. Many users layer it with their existing protocol. If you're unsure, bring the ingredient list to your doctor.

What if it doesn’t work for me?

90 days. Every dollar back. Use the whole jar. No return of unused product required.

*The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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